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Office: Science-2009
Phone: 641-269-4544
Email: levandos@grinnell.edu
B.S. 1990, University of Chicago.
Ph.D. 1995, University of Wisconsin at Madison.
Postdoctoral Fellow 1996-99, Brown University.
Professor Levandoski is interested in the determinants of specifity in complexes
involving biomolecules, in particular those of nicotinic acetylcholine receptors and their
ligands. This important family of proteins mediates the effects of tobacco smoking and
has been implicated in several major human nervous system disorders such as
schizophrenia and Parkinson's and Alzheimer's diseases. A related research interest
is the use of thermodynamic and kinetic analyses of binding specificity. [Full description PDF]
Neuroscience at Grinnell.
Biological Chemistry at Grinnell.
- BCM 262 Introduction to Biological Chemistry
- CHM 100 Chemistry is Everywhere
- CHM 129 General Chemistry
- CHM 210 Inorganic & Analytical Chemistry (formerly 130)
- CHM 332 Biophysical Chemistry
- CHM 363 Physical Chemistry I Laboratory
- CHM 390 Aquaporins (Special Topic Seminar)
- NRS 495 Neuroscience Seminar
- TUT (Tutorial) Place and Space: Through Process to Product
- Levandoski, M.M., Robertson, A.P., Kuiper, S., Qian, H., and Martin, R.J. (2005) Single-channel properties of N- and L-subtypes of acetylcholine receptor in Ascaris suum. Int. J. Parasitol. 35, 925-934.
- Kalodimos, C.G., Bonvin, A.M.J.J., Levandoski, M.M., Guennuegues, M., Boelens, R., and Kaptein, R. (2004) Structure adaptation and flexibility enhancement along the protein-DNA recognition pathway. Science 305, 386-389.
- Levandoski, M.M., *Piket, B., and *Chang, J. (2003) The anthelmintic levamisole is an allosteric modulator of human neuronal nicotinic acetylcholine receptors. Eur. J. Pharmacol. 471, 9-20.
* indicates student author
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