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May 2000
The brain, the nervous system, the final frontier. As we put together this inaugural
issue of Pioneering Neuroscience, there is both unmitigated enthusiasm and
cautious skepticism that the mysteries of the nervous system will yield to scientific
scrutiny. Bold advances in understanding and treating human depression must be
tempered with continued inability to bridge the gap between behavioral and molecular
understandings of complex neural processes, such as learning and memory.
Both sides of this dichotomy are represented in the first issue of
Pioneering Neuroscience. Some of the papers have clearly furthered our
understanding of the behavioral and/or cellular mechanisms involved in the nervous
system's response to neuroactive substances such as Dopamine, Glutamate,
Serotonin, nicotine, herbicides, and alcohol. However, in this same issue, other
papers have revealed our fundamental ignorance of the nervous system. Fundamental
Cellular mechanisms involving the role of intracellular calcium in synaptic plasticity and
the sensitivity of synaptic vesicle recycling to pH may not be as simple as previously
thought.
As with any frontier, the road forward is uncertain and fraught with unanticipated
setbacks and successes. Such is the life and the work of a pioneer. In that spirit, we
proudly present the first issue of Pioneering Neuroscience.
We wish to thank the students of Biology 363 (pictured below) for their contributions
to this journal, the National Science Foundation for its support of Nancy via an
NSF-AIRE grant and, most importantly, Vicki Wade for her publishing expertise.
Respectfully submitted,
Clark Lindgren & Nancy Rempel-Clower, Editors
May 20, 2000, Grinnell, Iowa
The crayfish fast extensor muscle exhibits both NMDA and non-NMDA receptor activity. [Blank.pdf]
V. Blank, A.C. Donahue & G. Spector
Time dependent effects of ethanol on excitatory junction potentials in the superficial extensor muscle of the crayfish tail. [HEINEM.pdf]
R. H. Heineman, M.S. Karafin & E.A. Staley
The behavioral and resting membrane potential responses to acute and chronic ethanol exposure. [Fausto.pdf]
J. Fausto, L. Haberl & R. Tiwari
Serotonin increases flexion and excitatory junction potential amplitude while octopamine decreases average excitatory junction potential amplitude in crayfish. [brummer.pdf]
M. Brummer, E. Lowe & B. Raore
Extracellular application of Trans-1-Amino-1, 3-Cyclopentane Dicarboxylic acid results in depression of excitatory junction potentials over time at the superficial extensor muscle in crayfish. [ARNONE.pdf]
N. Arnone, M. Johnston & M. Prekker
BAPTA-AM has no significant effects on synaptic plasticity at the crayfish lateral extensor neuromuscular junction. [BAILEY.pdf]
A. Bailey, M. Samuelson & L. Steinmetz
Dopaminergic modulation of excitatory junction potentials at the crayfish neuromuscular junction. [CHARNET.pdf]
M. Charnetski, M. Palta & R. Sahu
The effects of Serotonin and Fluoxetine on neurotransmission in crayfish superficial extensor muscle. [Dunn.pdf]
B. Dunnette, A. Shai & J. Shin
Behavioral and electrophysiological effects of ethanol on crayfish. [Chang.pdf]
M. Chang, C. Efe & M. Patel
Chronic exposure to RoundUp® Ready to Use Weed and Grass Killer increases the resting membrane potential of crayfish lateral extensor muscle cells. [JOHNSON.pdf]
R. L. Johnson, G. M. Kizer & J. L. Loucks
Nicotine induces an increase in excitatory junctional potential amplitude at the crayfish neuromuscular junction and desensitization after prolonged nicotine exposure. [BLANKENS.pdf]
M. A. Blankenship, E.M. Graf & A. F. Hendrickson
Propionic acid reversibly enhances synaptic depression during tetanic stimulation of the crayfish neuromuscular junction. [LESTER.pdf]
L. Lester, A. Pero & A. Pezalla
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