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September 2002
The tradition continues and, once more, we are breaking new ground. The first
volume of Pioneering Neuroscience contained articles that were contributed by a
dvanced students in Biology 363: Neurobiology. The following year, we chose to
create a second volume of Pioneering Neuroscience that contained articles written
exclusively by introductory students taking Biology 150: Introduction to Biological
Inquiry; The Language of Neurons. Now, in this the third volume, we have put
together a volume that combines these two classes and includes articles contributed
by students in both courses. The result is a journal that covers a wider range of
questions and presents a greater range of techniques and experimental preparations.
For those of you who might be interested, students in Biology 363 wrote the first
three articles in Volume 3 of Pioneering Neuroscience. As you can see, these papers
all describe experiments that were performed on the nerve-muscle preparation from
the Sartorius muscle in the frog. The classic frog neuromuscular junction is still one
of the best preparations for asking questions about synaptic physiology. The
remaining eight articles were provided by students taking Biology 150 and all use the
nerve-muscle synapse in the superficial extensor muscle in the tail of the crayfish.
The relatively "simple" preparation continues to provide valuable insights into the
process of synaptic transmission. Little by little, both preparations are helping us to
understand the language of neurons.
Clark Lindgren and Nancy Rempel-Clower, Editors
December 2001, Grinnell, Iowa
Pioneering Neuroscience Volume 3 Cover; cover art © 2000 Helen Carey [Cover_PN3.pdf]
Table of Contents [Contents_PN3.pdf]
Introduction, by Clark Lindgren & Nancy Rempel-Clower [Intro_PN3.pdf]
ORIGINAL ARTICLES
Soluble guanylate cyclase inhibitor prevents depression after moderate frequency stimulation and during cGMP-analogue treatment at the frog neuromuscular junction. [01-05_PN3.pdf]
A. Mikulyuk & M. Morotani
ATP depresses end-plate potential amplitude through nitric oxide-independent pathways in the frog neuromuscular junction. [7-10_PN3.pdf]
E. Paesch, J. Heard & B. Lake
Nitric oxide synthase inhibitor reduces muscarinic-mediated depression of EPP values at the frog neuromuscular junction. [11-16_PN3.pdf]
J. N. Schmidt & K. M. Young
BAPTA-AM and Dibromo BAPTA-AM both decrease the amplitude of EPSPs in the crayfish neuromuscular juction, but have minimal effect on synaptic facilitation. [17-20_PN3.pdf]
G. Calhan, S. Cramer & D. Flores
L-2-Amino-3-phosphonopropionic acid modulates the release of glutamate by blocking presynaptic group II mGlu receptors at neuromuscular junction in Procambarus clarkii. [21-26_PN3.pdf]
P. Ames, N. Heto & R. Ramdial
Thapsigargin depletes calsium stores within the endoplasmic reticulum and decreases the peak EPSPs achieved in associated muscle cells after extended periods of high frequency stimulation. [27-30_PN3.pdf]
M. Mircetic & N. Casado
The neuropeptide DF2 decreases the EPSP amplitude in the crayfish neuromuscular juction with a lessened effect at lower temperatures and with crayfish chronically exposed to lower temperatures. [31-35_PN3.pdf]
E. Conboy, J. Swanson & K. Tran
Inhibition of the reverse mode of the sodium/calcium exchanger reduces facilitation of paired excitatory postsynaptic potentials in the crayfish neuromuscular junction. [37-40_PN3.pdf]
T.-K. Lin, K. Kessler & C. MacKuen
Fluoxetine and hyperforin appear to act like a known glutamate reuptake inhibitor by increasing EPSP duration in the crayfish neuromuscular junction. [41-44_PN3.pdf]
A. Hoye, D. Mitchell & A. Tucker
A molting hormone, 20-hydroxyecydsone appears to reduce synaptic efficacy in crayfish fast extensor muscle fibers by binding to the presynaptic glutamate autoreceptors. [45-48_PN3.pdf]
K. Hodes, M. H. Aung & S. Yang
Increased EPSP amplitude at the crayfish neuromuscular junction for acute but not chronic exposure to fluoxetine. [49-52_PN3.pdf]
A. Graves, K. McCarthy & E. Mudoh
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