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December, 2008
It is my pleasure to present the ninth volume of Pioneering Neuroscience: The Grinnell
Journal of Neurophysiology. The articles collected in this volume represent original
contributions to the field of Neuroscience offered by students in Biology 150 --
Introduction to Biological Inquiry: the Language of Neurons. For most of these students,
Bio 150 was taken during their first semester in college. For all of the students, this was
their first college-level biology course!
The articles in this volume explore several themes: the use of kiss-and-run fusion during
neurotransmitter release, the modulation of neurotransmitter release by the gasses NO
and H2S, the role of glutamate uptake and recycling and the possible involvement of
endocannabinoids in synaptic function. There was even a highly novel attempt to
observe the process of hormesis (if you don’t know what this is, you can read about it on
page 17). Of course, all of this was done using the wonderful model system of the
crayfish neuromuscular junction. I hope you enjoy this volume and trust you will be as
impressed as I am with what these students have accomplished in such a short time.
I wish to thank the students of Biology 150 for their hard work and collegiality. None of
this would have been possible without the major contributions of Sue Kolbe, the lab
instructor for Biology 150, Abby Griffith ’07, curricular assistant, and Courtney Smith
’08, student mentor and lab assistant.
Clark Lindgren, Editor, Grinnell, Iowa
Pioneering Neuroscience Volume 9
Table of Contents [TOC.pdf]
Introduction [Intro.pdf]
ORIGINAL ARTICLES
Kiss-and-Run fusion can be detected at the crayfish neuromuscular junction.
L. Hunter, J. Jackson, and N. Maurer
Simultaneous application of H2S and inhibition of its endogenous production induces disparate synaptic response at the crayfish neuromuscular junction.
B. Bell, M. Cole, and G. Jacobs
Inhibiting endogenous hydrogen sulfide production decreases amplitudes of EPSPs at the crayfish neuromuscular junction.
C. Brooke-deBock, J. King, and S. Sherwood
Nitric oxide inhibition shortens long-term facilitation at the neuromuscular junction of the crayfish.
M. Hochstein
Effect of a calcium ionophore in the process of hormesis at the crayfish neuromuscular junction.
K. Norton, S. Ghattass, and C. Barrios-Camacho
Endocannabinoids inhibit EPSPs at the crayfish neuromuscular junction.
C. Johnston, J. Joubert, and N. Osman
Inhibition of glutamate transporters decreases the amplitude of excitatory postsynaptic potential at the crayfish neuromuscular junction.
T. Cohen, P. Frimpong, and M. Scharf
The addition of Methionine Sufoximine, an inhibitor of the Glutamate-Glutamine cycle, decreases excitatory post-synaptic potentials in Orconectes sanbarnii muscle cells.
H. Kubieck, A. Ross and P. Sahu
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