Neuroscience

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  ABSTRACT 5-HT is known to increase the amplitude of excitatory postsynaptic potentials (EPSPs) in the crayfish neuromuscular junction, but it is not known how 5-HT does this. It is possible that 5-HT acts through IP3-induced intracellular Ca2+release. To test this, we bathed a...
  ABSTRACT 5-HT is known to increase the amplitude of excitatory postsynaptic potentials (EPSPs) in the crayfish neuromuscular junction, but it is not known how 5-HT does this. It is possible that 5-HT acts through IP3-induced intracellular Ca2+release. To test this, we bathed a...
  View this article as PDF: Garwood, Papachristoudis, Peralta, and Rowlison ABSTRACT Internal calcium stores have been shown to have an effect on synaptic transmission. Our objective in this experiment was to see how the depletion or inhibition of internal calcium stores would...
  View this article as PDF: Garwood, Papachristoudis, Peralta, and Rowlison ABSTRACT Internal calcium stores have been shown to have an effect on synaptic transmission. Our objective in this experiment was to see how the depletion or inhibition of internal calcium stores would...
  Grinnellians in Neuroscience: Foundations, Future, and Fallacies, a 200-level neuroscience course, celebrated Brain Week 2013 with Grinnell Middle School students. The students hosted them at the college and lead them through neuroscience-related activities such as: Seeing how...
  Grinnellians in Neuroscience: Foundations, Future, and Fallacies, a 200-level neuroscience course, celebrated Brain Week 2013 with Grinnell Middle School students. The students hosted them at the college and lead them through neuroscience-related activities such as: Seeing how...
  ABSTRACT Ca2+/calmodulin (CaM) is a protein that can bind to and activate a variety of target proteins within the pre- and postsynaptic cells of the neuromuscular junction (NMJ). An important presynaptic CaM target is CaM-kinase II (CaMKII). Upon activation, CaMKII has been...
  ABSTRACT Ca2+/calmodulin (CaM) is a protein that can bind to and activate a variety of target proteins within the pre- and postsynaptic cells of the neuromuscular junction (NMJ). An important presynaptic CaM target is CaM-kinase II (CaMKII). Upon activation, CaMKII has been...
  View this article as PDF: Goldsmith, Granera, and Wolfe ABSTRACT Argireline is an anti-wrinkle agent that is proposed to work in the presynaptic cell of the neuromuscular junction by mimicking the structure of a presynaptic protein and preventing the interaction between SNARE...
  View this article as PDF: Goldsmith, Granera, and Wolfe ABSTRACT Argireline is an anti-wrinkle agent that is proposed to work in the presynaptic cell of the neuromuscular junction by mimicking the structure of a presynaptic protein and preventing the interaction between SNARE...
  ABSTRACT Synaptic plasticity is a fundamental property of the vertebrate central nervous system and is thought to be involved in learning and memory processes. In the presynaptic terminal, mitochondria regulate synaptic plasticity by influencing neurotransmitter release. To...
  ABSTRACT Synaptic plasticity is a fundamental property of the vertebrate central nervous system and is thought to be involved in learning and memory processes. In the presynaptic terminal, mitochondria regulate synaptic plasticity by influencing neurotransmitter release. To...
  ABSTRACT Endocannabinoids are involved in retrograde messaging in neurons. Recent studies have found evidence of endocannabinoids and CB1 receptors at the neuromuscular junction of vertebrates as well as in some invertebrates. We attempted to explain how endocannabinoids...
  ABSTRACT Endocannabinoids are involved in retrograde messaging in neurons. Recent studies have found evidence of endocannabinoids and CB1 receptors at the neuromuscular junction of vertebrates as well as in some invertebrates. We attempted to explain how endocannabinoids...
  ABSTRACT Nitric oxide (NO) plays a critical role in the CNS in higher animals and at the lizard neuromuscular junction (NMJ), modulating synaptic transmission. However, whether this role is conserved at the crayfish NMJ remains unclear. In this study, we attempted to determine...
  ABSTRACT Nitric oxide (NO) plays a critical role in the CNS in higher animals and at the lizard neuromuscular junction (NMJ), modulating synaptic transmission. However, whether this role is conserved at the crayfish NMJ remains unclear. In this study, we attempted to determine...
  ABSTRACT Fluoxetine (Prozac) is a frequently prescribed antidepressant, identified as a selective serotonin reuptake inhibitor. Prozac’s function as an SSRI leads to the popular belief that its antidepressant mechanism is related simply to an increased serotonin level in the...
  ABSTRACT Fluoxetine (Prozac) is a frequently prescribed antidepressant, identified as a selective serotonin reuptake inhibitor. Prozac’s function as an SSRI leads to the popular belief that its antidepressant mechanism is related simply to an increased serotonin level in the...
  ABSTRACT The aim of this experiment was to explore the effects of the neuropeptide FMRFamide (FMRFa) on the crayfish neuromuscular junction (CNJ). In previous experiments, DF2, a FMRFa-like peptide, has been shown to increase neurotransmitter (NT) release at the CNJ. We...
  ABSTRACT The aim of this experiment was to explore the effects of the neuropeptide FMRFamide (FMRFa) on the crayfish neuromuscular junction (CNJ). In previous experiments, DF2, a FMRFa-like peptide, has been shown to increase neurotransmitter (NT) release at the CNJ. We...
  ABSTRACT Fluorescent dyes and confocal fluorescence microscopy were used to localize nerve terminals and adjacent cells in crayfish abdominal muscles. Nerve terminals were stained with 4-di-2-aspm (4-diethylaminostryly-N-methylpyridinium iodide) and nuclei of adjacent cells...
  ABSTRACT N-acetylaspartylglutamate (NAAG) is the most abundant peptide neurotransmitter in the mammalian central nervous system. It is composed of aspartate and glutamate, two fundamental amino acids, and modulates synaptic transmission via the activation of group II...
  View this article as PDF: Morley, Shriver, and Zhang ABSTRACT This experiment looked at the role of nitric oxide in the mechanism by which the peptide DF2 increases neurotransmitter release at the crayfish neuromuscular junction. We hypothesized that if DF2 increases...
    ABSTRACT Nitric oxide (NO) is a compound that acts as a retrograde messenger in a variety of organisms. It also plays a role in the strengthening of synapses and facilitation of synaptic plasticity. In our study, we asked whether NO plays a similar role in the crayfish...
  ABSTRACT We studied the neurohormone octopamine, attempting to determine if the cGMP pathway is involved in the modulation of synaptic transmission by octopamine in Procambarus clarkii muscle cells. We applied a soluble guanylyl cyclase inhibitor (ODQ) along with octopamine in...
  ABSTRACT The classical mode of neurotransmitter release, full collapse fusion (FCF), occurs when a vesicle is completely incorporated into the presynaptic membrane. Growing evidence supports a novel additional mode of neurotransmitter release known as “kiss-and-run” (K&R)...
ABSTRACT Endocannabinoids are a widely studied family of molecules that act as neurotransmitters and influence synaptic plasticity. Endocannabinoids have been extensively studied in the frog and lizard neuromuscular junction. However, this study assessed the effects of...
  ABSTRACT Ca2+ is a key second messenger in many organisms; this include being essential for neurotransmitter release. Control of extracellular Ca2+ ([Ca2+]o) is critical in the human body; imbalances are associated with a large variety of neurological disorders. The Calcium...
  ABSTRACT Ca2+ is a key second messenger in many organisms; this include being essential for neurotransmitter release. Control of extracellular Ca2+ ([Ca2+]o) is critical in the human body; imbalances are associated with a large variety of neurological disorders. The Calcium...
  View this article as PDF: Furstenau, Hazeltine, and Miller - PNv10 PDF   ABSTRACT SNARE proteins play an essential role in neurotransmission. Impaired SNARE function inhibits neurotransmission by blocking exocytic membrane fusion. Using intracellular microelectrodes, we...
  View this article as PDF: Furstenau, Hazeltine, and Miller - PNv10 PDF   ABSTRACT SNARE proteins play an essential role in neurotransmission. Impaired SNARE function inhibits neurotransmission by blocking exocytic membrane fusion. Using intracellular microelectrodes, we...
  ABSTRACT The neurotransmitter octopamine raises the amplitude of excitatory post-synaptic potentials (EPSP) in crayfish (Procambarus clarkii). Previous studies have ruled out a connection between octopamine’s effects and cAMP or cGMP systems, suggesting another secondary...
  ABSTRACT The neurotransmitter octopamine raises the amplitude of excitatory post-synaptic potentials (EPSP) in crayfish (Procambarus clarkii). Previous studies have ruled out a connection between octopamine’s effects and cAMP or cGMP systems, suggesting another secondary...
  View this article as PDF: Macfarlane, Most, and Zucker ABSTRACT Endocannabinoids are retrograde transmitters, which inhibit the release of neurotransmitters. We hypothesized that endocannabinoids would operate similarly in crayfish neuromuscular junctions as they do at other...
  View this article as PDF: Macfarlane, Most, and Zucker ABSTRACT Endocannabinoids are retrograde transmitters, which inhibit the release of neurotransmitters. We hypothesized that endocannabinoids would operate similarly in crayfish neuromuscular junctions as they do at other...
Students are working as neuroscientists in Clark Lingren’s The Language of Neurons, an introduction to biology course. In 2000, Grinnell College turned the biology curriculum upside down, involving entry-level biology students in cutting-edge research and offering a unique,...
Students are working as neuroscientists in Clark Lingren’s The Language of Neurons, an introduction to biology course. In 2000, Grinnell College turned the biology curriculum upside down, involving entry-level biology students in cutting-edge research and offering a unique,...

Group Info

As a neuroscience concentrator, you use methods and theories spanning disciplines from biochemistry to psychology to investigate the function of the nervous system. You can participate in an annual neuroscience retreat, middle school outreach, and a capstone seminar, along with...
As a neuroscience concentrator, you use methods and theories spanning disciplines from biochemistry to psychology to investigate the function of the nervous system. You can participate in an annual neuroscience retreat, middle school outreach, and a capstone seminar, along with...

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