Home » User account » praitis » praitis

Vida Praitis

Personal

Personal

Vida

Developmental Genetics and Cell Biology

Directed changes in the shape of epithelial sheets are required to create many of the major tissues in animals, including the intestinal system, kidneys, lungs, and skin. Although our understanding of epithelial sheet morphogenesis has advanced in recent years, we still have much to learn about this fundamental developmental process. Research in my laboratory focuses on understanding at a cellular and molecular level the mechanisms by which epithelial sheets change shape during their development. I have chosen to study epithelial shape change in the model system C. elegans because it occurs in a simple, predictable fashion, allowing us to characterize this process at a genetic, cellular and organismal level. During C. elegansembryogenesis epithelial cells elongate over four-fold, driven by dramatic changes in the organization of all major cytoskeletal structures. Because the forces that drive cell shape change act on the apical membrane skeleton of epithelial cells, this structure must be both strong and dynamic. One protein that localizes to the apical membrane skeleton and is required for epithelial cell shape change is SMA-1 spectrin, an ortholog of Drosophila H-spectrin and human V-spectrin. sma-1 mutants fail to elongate properly during embryogenesis. Our analysis of sma-1mutants has shown that SMA-1 has two discreet functions in epithelial elongation: to maintain the association of actin at the apical membrane and to preserve changes in the organization of the apical membrane. Ongoing research aims to better understand these roles for SMA-1 spectrin and to identify the proteins that interact with SMA-1 in epithelial morphogenesis. As a result of these studies, we will gain fundamental insights into how changes in the apical membrane skeleton contribute to epithelial cell elongation, a process fundamental to the development of all animals.

Campus Phone: 
(641) 269-4390
Fax: 
(641) 269-4984

Faculty

Faculty

faculty info column 1

On-Campus Address: 
1820 Science
Grinnell, IA
United States
Education / Degrees: 
B.A. 1988, Swarthmore College, Ph.D. 1995, M.I.T., Post-Doc, 1995-2001, U. of Chicago,
Courses Taught: 
Biology 150: Introduction to Biological Inquiry, "Cell Fate: Calvin or Hobbes?" Biology 251: Molecules, Cells, and Organisms, with Lab Biology 345: Advanced Genetics, with Lab Biology 355: Developmental Genetics, with Lab Biology 370: Topics in Cell Biology Biology 295: Special Topic, Bioinformatics Biological Chemistry 262L: Introduction to Biological Chemistry Lab Tutorial: "Trouble Helix: How Modern Genetics Has Changed Our View of Humanity"
Primary Academic Interest: 
Developmental Genetics and Cell Biology
Position: 
Associate Professor
Curriculum Vitae/Resume: