Ernesto Manzo

How do neurons degenerate? This is the central question that drives my research. Neuronal loss is a defining feature of many neurological disorders, yet we still have a surprisingly limited understanding of how neurons activate the self-destruction programs that lead to axon and synapse loss. If we can identify the molecules that trigger these pathways, we may be able to develop strategies that preserve neural function in disease and after injury. 

To answer these questions, I use the fruit fly, Drosophila melanogaster, as a model organism. Although flies and humans seem very different, many of the molecular pathways that control neuronal survival are remarkably conserved. My laboratory combines genetics, imaging, and behavioral approaches to identify the signals that determine whether neurons survive or degenerate. 

My interest in biology began as an undergraduate at Swarthmore College, where I worked at the Clinic for Special Children studying genetic diseases in Amish and Mennonite Plain populations. Seeing how genetic discoveries could directly improve human health inspired me to pursue a career in research. After teaching middle school science for two years, I earned my Ph.D. at the University of Arizona studying a fruit fly model of ALS and later completed postdoctoral training with Marc Freeman at Oregon Health & Science University. 

As the son of Mexican immigrants and a first-generation college graduate, I view education as a powerful opportunity to expand one's understanding of the world. In my teaching and mentoring, I strive to create the same sense of support and belonging that helped me succeed as a student. I enjoy helping students develop confidence in their ability to think critically, ask questions, and participate in the process of scientific discovery. 

Outside of the laboratory, I enjoy soccer (playing, coaching, watching), running, hiking, biking, and spending time with my wife and our three daughters.